Publications
With over 500 publications, we have build a strong track record of research and expertise. The following is a curated selection of key articles specifically related to the services we offer, highlighting the impact and innovation behind our work.
This study compares kidney function of perfused porcine and human kidneys
Lantinga VA, Arykbaeva AS, Spraakman NA, Blom EWP, Huijink TM, de Vries DK, Ploeg RJ, Alwayn IPJ, Leuvenink HGD, Moers C, van Leeuwen LL. Impact of device variability and protocol differences on kidney function during normothermic machine perfusion: A comparative study using porcine and human kidneys. Artif Organs. 2025 Jan;49(1):93-107. doi: 10.1111/aor.14851
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This study is a good example of combining machine perfusion with slice incubations to assess drug effects
van Leeuwen LL, Ruigrok MJR, Kessler BM, Leuvenink HGD, Olinga P. Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model. Br J Pharmacol. 2024 Feb;181(3):464-479. doi: 10.1111/bph.16220.
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This article provides insights into the most effective oxygen delivery methods during machine perfusion for improving kidney transplant outcomes.
Pool MBF, Rozenberg KM, Lohmann S, Ottens PJ, Eijken M, Keller AK, Jespersen B, Ploeg RJ, Leuvenink HGD, Moers C. Ex-Vivo Kidney Perfusion With Hemoglobin-Based Oxygen Carriers, Red Blood Cells, or No Oxygen Carrier. J Surg Res. 2024 Sep;301:248-258
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This study highlights how NETs contribute to inflammation and graft injury, offering insights into potential therapeutic strategies to improve transplant outcomes.
van Zyl M, Cramer E, Sanders JF, Leuvenink HGD, Lisman T, van Rooy MJ, Hillebrands JL. The role of neutrophil extracellular trap formation in kidney transplantation: Implications from donors to the recipient. Am J Transplant. 2024 Sep;24(9):1547-1557. doi: 10.1016/j.ajt.2024.04.018
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In this article we combined machine perfusion with magnetic resonance imaging (MRI) for evaluation of treatment outcomes.
Rodriguez RD, Huizing E, Ünlü Ç, Simonis FFJ, Bokkers RPH, de Vries JPM, Schuurmann RCL, Nakladal D, Buikema H, Hillebrands JL, Leuvenink HGD. Validation of an ex vivo Flow Model Including Magnetic Resonance Imaging to Study the Effects of Endovascular Treatments on the Arterial Wall. J Vasc Res. 2023;60(1):1-11. doi: 10.1159/000529115.
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Both these study shows the application of drugs in machine perfusion protocol either during NMP (Ogurlu et al) or HMP (Leeuwen et al).
van Leeuwen L, Venema LH, Heilig R, Leuvenink HGD, Kessler BM. Doxycycline Alters the Porcine Renal Proteome and Degradome during Hypothermic Machine Perfusion. Curr Issues Mol Biol. 2022 Jan 23;44(2):559-577. doi: 10.3390/cimb44020039. PMID: 35723325; PMCID: PMC8928973.
Ogurlu B, Hamelink TL, Lantinga VA, Leuvenink HGD, Pool MBF, Moers C. Furosemide attenuates tubulointerstitial injury and allows functional testing of porcine kidneys during normothermic machine perfusion. Artif Organs. 2024 Jun;48(6):595-605. doi: 10.1111/aor.14705.
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Review that describes the potential of supplementation of perfusion solutions with drugs during the perfusion offer a promising strategy to optimize the organ and improve transplant outcomes
van Leeuwen LL, Leuvenink HGD, Olinga P, Ruigrok MJR. Shifting Paradigms for Suppressing Fibrosis in Kidney Transplants: Supplementing Perfusion Solutions With Anti-fibrotic Drugs. Front Med (Lausanne). 2022 Jan 10;8:806774. doi: 10.3389/fmed.2021.806774
One of the first publications about the potential of machine perfusion for transplantation medicine
van der Plaats A, ’t Hart NA, Verkerke GJ, Leuvenink HGD, Ploeg RJ, Rakhorst G. Hypothermic machine preservation in liver transplantation revisited: concepts and criteria in the new millennium. Ann Biomed Eng. 2004 Apr;32(4):623-31. doi: 10.1023/b:abme.0000019181.18194.51.
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